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-synuclein, which is a primary element of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and results in endoplasmic reticulum (ER) worry, suggest that dysfunction of your intracellular proteinase systems, like ubiquitin-proteasome method or lysosomal program, which eliminates unneeded poisonous pro
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